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US 7,582,295 B2Granted
Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy
AssigneeUniversity of Zurich
InventorsRoger Ariel Alberto, Pascal Jean-Marie Hafliger
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Abstract
The invention relates to molecules for treatment and diagnosis of tumors and malignancies, comprising a tumor seeking biomolecule, which is coupled to an intercalating moiety, which is capable of complexing a metal, which metal is preferably a radioactive metal, to the use of these molecules and to therapeutic and diagnostic compositions containing them.
Claims33
A compound comprising:
- a moiety having an affinity for cancer cells;
- an intercalating moiety coupled to the moiety having an affinity for cancer cells, wherein the intercalating moiety comprises at least one unsubstituted aromatic ring that shares two carbons with only one other aromatic ring, and is configured to insert into the structure of deoxyribonucleic acid, and wherein the intercalating moiety is functionalized with a ligand configured to coordinate a [metal(CO)3]+ moiety;
- and
- a metal complexed with the ligand attached to the intercalating moiety.
1 more element
A composition comprising:
- an excipient;
- and
- a compound comprising:
- a moiety having an affinity for cancer cells;
- an intercalating moiety coupled to the moiety having an affinity for cancer cells, wherein the intercalating moiety comprises at least one unsubstituted aromatic ring that shares two carbons with only one other aromatic ring, and is configured to insert into the structure of deoxyribonucleic acid, and wherein the intercalating moiety is functionalized with a ligand configured to coordinate a [metal(CO)3]+ moiety;
- and
- a metal complexed with the ligand attached to the intercalating moiety, wherein the metal comprises Tc-99m, Re-186, Re-188, or Mn, or combinations thereof.
4 more elements
A method of using a composition, the method comprising:
- administering a composition to a medical patient, wherein the composition includes a compound comprising:
- a moiety having an affinity for cancer cells;
- an intercalating moiety coupled to the moiety having an affinity for cancer cells, wherein the intercalating moiety comprises at least one unsubstituted aromatic ring that shares two carbons with only one other aromatic ring, and inserts into the structure of deoxyribonucleic acid, and wherein the intercalating moiety is functionalized with a ligand configured to coordinate a [metal(CO)3]+ moiety;
- and
- a metal complexed with the ligand attached to the intercalating moiety, wherein the ligand and the intercalating moiety provide at least a bidentate coupling to the metal.
2 more elements
A compound comprising:
- a tumor seeking molecule, wherein the tumor seeking molecule has an affinity for a cancer cell, a tumor, or both;
- an intercalating moiety comprising a planar, heterocyclic aromatic ring structure coupled to the tumor seeking molecule, wherein the planar heterocyclic aromatic ring structure comprises at least one unsubstituted aromatic ring fused to only one other aromatic ring by two carbons, and wherein the intercalating moiety is functionalized with a ligand configured to coordinate a [metal(CO)3]+ moiety;
- and
- a metal complexed with the ligand attached to the intercalating moiety.
1 more element
Dependencies are inferred from the claim text.