Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
AssigneeThe Rockefeller University
InventorsPauline Yoong, Raymond Schuch, Daniel Nelson, Vincent A. Fischetti
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Abstract
The present disclosure relates to bacteriophage lysins useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial infections. For example, bacteriophage lysins were isolated and shown to effectively kill various bacteria, including both E. faecalis and E. faecium (including vancomycin resistant strains), as well as other human pathogens.
Claims27
A therapeutic composition comprising an isolated polypeptide comprising the isolated amino acid sequence of SEQ ID NO:1 the therapeutic composition having killing activity against one or more enterococcal bacteria.
A method of treating an enterococcal bacterial infection, the method comprising the step of administering to a patient having an enterococcal bacterial infection, a therapeutic composition comprising an isolated amino acid sequence comprising the polypeptide of SEQ ID NO:1.
A method for treating an enterococcal infection comprising the step of administering a composition to a subject comprising at least one bacteriophage lysin comprising at least the amino acid sequence of SEQ ID NO:1 or a polypeptide variant of SEQ ID NO:1 in which one or more amino acid residues are conservatively substituted, where the bacteriophage lysin has a lytic killing activity against E. faecalis V12.
A therapeutic composition comprising a polypeptide having an amino acid sequence which has at least 95% identity with the amino acid sequence of SEQ ID NO:1, wherein the therapeutic composition has killing activity against one or more enterococcal bacteria.
A composition comprising an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:1 the composition having killing activity against one or more enterococcal bacteria.
Dependencies are inferred from the claim text.