Viruses for the treatment of cellular proliferative disorders
AssigneeOncolytics Biotech Inc.
InventorsMatthew C. Coffey, Bradley G. Thompson
Life of this patent
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Abstract
Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering a immunosuppressive agent.
Claims18
A method for treating a Ras-mediated cell proliferative disorder in a mammal, comprising contacting proliferating cells having a Ras-activated pathway with an effective amount of at least one modified parapoxvirus orf virus under conditions which result in substantial lysis of the proliferating cells, wherein the modified parapoxvirus orf virus comprises a mutation in the OV20.0L gene.
A method for treating a Ras-mediated proliferative disorder in a mammal, comprising the steps of:
- a) performing a step selected from the group consisting of:
- i) administering to the proliferating cells in said mammal an effective amount of an immune suppressive agent;
- ii) removing B-cells or T-cells from said mammal;
- iii) removing anti-parapoxvirus orf virus antibodies from said mammal;
- iv) removing antibodies from said mammal;
- v) administering anti-anti-parapoxvirus orf virus antibodies to said mammal;
- and
- vi) suppressing the immune system of the mammal;
- and
- b) administering to said mammal an effective amount of at least one modified parapoxvirus orf virus under conditions which result in substantial lysis of the proliferating cells, wherein the modified parapoxvirus orf virus comprises a mutation in the 0V20.0L gene.
Dependencies are inferred from the claim text.