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US 7,582,288 B2Granted
Methods of targeting multiple cytokines
AssigneeMerck Patent GmbH
InventorsStephen D. Gillies, Kin-Ming Lo
Life of this patent
Estimating the term…
Abstract
The invention relates to protein complexes and fusion proteins including at least two different cytokine molecules. The protein complexes and fusion proteins may further include a targeting moiety such as a region of an immunoglobulin. Methods of using the protein complexes and fusion proteins are also disclosed.
Claims6
A method of targeting a first cytokine (C1) and a second, different cytokine (C2) in a mammal, the method comprising:
- administering to the mammal a multifunctional fusion protein comprising a C1, a C2, and an immunoglobulin region (Ig) capable of targeting said fusion protein in the mammal,
- wherein C1 comprises IL-12 and C2 comprises a chemokine or a four-helix bundle cytokine.
Dependencies are inferred from the claim text.