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US 7,582,281 B2Granted
Ethylenedicysteine (EC)-drug conjugates compositions and methods for tissue specific disease imaging
AssigneeBoard of Regents, The University of Texas System
InventorsDavid J. Yang, Chun W. Liu, Dong-Fang Yu, E. Edmund Kim
Life of this patent
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Abstract
The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.
Claims44
A method of imaging a site within a subject comprising the steps of:
- a) administering to the subject an effective amount of a composition comprising a radionuclide-labeled bis-aminoethanethiol (BAT)-targeting ligand conjugate, wherein the BAT comprises two carboxylic acid moieties and wherein a targeting ligand is conjugated to at least one carboxylic acid moiety of the BAT;
- and
- b) detecting signal from the site.
Dependencies are inferred from the claim text.