Methods for forming macroporous monolithic methylsilsesquioxanes
AssigneeMcMaster University
InventorsMichael A. Brook, John D. Brennan, Hanjiang Dong
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Abstract
The present invention relates to a two-step method of preparing methylsilsequixane (MSQ) materials suitable for chromatographic applications comprising treating a MSQ precursor with a suitable acid followed by treatment with a suitable base under conditions to form a MSQ monolith suitable for chromatographic applications.
Claims15
A two-step method of preparing methylsilsesquioxane (MSQ) materials suitable for chromatographic applications comprising treating a MSQ precursor with a suitable acid followed by treatment with a suitable base and controlling one or more of the reaction conditions selected from the group consisting of:
- (a) acid concentration;
- (b) time of acid treatment;
- and
- (c) total concentration of water,
- to provide a gelation time that is less than the phase separation time to form a MSQ monolith suitable for chromatographic applications;
- wherein the MSQ material is loaded into a chromatographic column before gelation occurs.
Dependencies are inferred from the claim text.