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US 7,579,477 B2Granted
Thiazole-based nitric oxide donors having alkyl substituent(s) and uses thereof
AssigneeRenopharm Ltd.
InventorsPeter Assaf, Elham Gazaleen-Mariee, Michael Naveh
Life of this patent
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Abstract
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
Claims2
An NO-donating compound selected from the group consisting of:
- 2-Ethyl-4-methyl-5-(2-nitrooxy-ethyl)-thiazole (Pet-2);
- 2-Isopropyl-4-methyl-5-(2-nitrooxy-ethyl)-thiazole (Pet-4);
- 4-Methyl-5-(nitrooxy-ethyl)-2-trifluoromethyl-thiazole (Pet-6);
- 4-Methyl-5-(2-nitrooxy-ethyl)-2-pentafluoroethyl-thiazole (Pet-45);
- 4-Methyl-5-(2-nitrooxy-ethyl)-2-(2-phenyl-propyl)-thiazole (Pet-46);
- C-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-methylamine (Pet-51);
- 2-[1-(4-Isobutyl-phenyl)-ethyl]-4-methyl-5-(2-nitrooxy-ethyl)-thiazole (Pet-66);
- 2-(4-[1,2]Dithiolin-3-yl-butyl)-4-methyl-5-(2-nitrooxy-ethyl)-thiazole (Pet-67);
- 4-Methyl-5-(2-nitrooxy-ethyl)-2-thiophen-2-ylmethyl-thiazole (Pet-86);
- 4-Methyl-5-(2-nitrooxy-ethyl)-2-(1-thiophen-2-yl-ethyl)-thiazole (Pet-87);
- 2-Isobutyl-4-methyl-5-(2-nitrooxy-ethyl)-thiazole (Pet-108);
- 1-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-2-phenyl-ethylamine (Pet-119);
- [4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-acetonitrile (Pet-114);
- 2-[1-(6-Methoxy-naphthalen-2-yl-ethyl]-4-methyl-5-(2-nitrooxy-ethyl)-thiazole (Pet-17);
- Amino-{3-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-propylamino}-acetic acid (Pet-112);
- and
- 3-Methyl-1-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-butylamine (Pet-49).
14 more elements
Dependencies are inferred from the claim text.