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US 7,579,379 B2Granted
CETP activity inhibitors
AssigneeJapan Tobacco Inc.
InventorsHisashi Shinkai, Kimiya Maeda, Hiroshi Okamoto
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AssigneeJapan Tobacco Inc.
InventorsHisashi Shinkai, Kimiya Maeda, Hiroshi Okamoto
Estimating the term…
The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X1, X2, X3, and X4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents —CO— or —SO2—, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof. The compounds represented by the formula (I) can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity and, therefore, is expected to be useful as a new type of a preventive or therapeutic agent for atherosclerosis or hyperlipidemia.
A compound having the structural formula
A compound having the structural formula selected from the group consisting of (a)
A method of preparing a compound of formula (1)
A method of preparing a compound of formula (1)
A method of preparing a compound of formula (1)
A method of inhibiting cholesterol ester transfer protein (CETP) activity in a patient, which method comprises providing
A method of increasing high density lipoprotein (HDL) in a patient, which method comprises providing
A method of treating or preventing atherosclerosis in a patient, which method comprises providing
A method of treating or preventing hyperlipidemia in a patient, which method comprises providing
Dependencies are inferred from the claim text.