Aligned scaffolds for improved myocardial regeneration
AssigneeSciMed Life Systems, Inc.
InventorsToby Freyman, Maria Palasis, Mark Ungs
Life of this patent
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Abstract
The present invention relates to a biocompatible, three-dimensional scaffold useful to grow cells and to regenerate or repair tissue in predetermined orientations. The scaffold is particularly useful for regeneration and repair of cardiac tissue. The scaffold contains layers of alternating A-strips and S-strips, wherein the A-strips within each layer are aligned parallel to each other and preferentially promote cellular attachment over attachment to the S-strips. Methods of producing and implanting the scaffold are also provided.
Claims23
A method for inducing tissue repair and regeneration which comprises surgically implanting a semi-solid three-dimensional biocompatible scaffold at a site in need of tissue repair or growth to thereby induce tissue repair and regeneration, wherein the scaffold is comprised of more than one scaffold layer of alternating attachment-strips (A-strips) and separating-strips (S-strips), the A-strips within each scaffold layer being aligned parallel to each other and the A-strips preferentially promoting cellular attachment to an A-strip over cellular attachment to an S-strip.
Dependencies are inferred from the claim text.