Antibodies specific for sclerostin
AssigneeCelltech R&D Limited
InventorsDavid G. Winkler, Jiye Shi, John Latham
Life of this patent
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Abstract
A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
Claims23
An isolated antibody, or an antigen-binding fragment thereof, that specifically binds to an epitope within amino acids 86-111 of SEQ ID NO:
- 46.
An isolated antibody, or antigen binding fragment thereof, that binds to a peptide consisting of amino acids 86-111 of SEQ ID NO:
- 46 with an affinity KD of less than or equal to about 10−7 M.
Dependencies are inferred from the claim text.