Salts of potassium ATP channel openers and uses thereof
AssigneeEssentialis, Inc.
InventorsNeil M. Cowen, Kenneth B. Kashkin, Khaled A. Yamout
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Abstract
Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.
Claims14
A salt comprising:
- a KATP channel opener selected from the group consisting of Formula III and Formula IV, and a counter ion as shown below
- wherein:
- R1 is selected from the group consisting of hydrogen, lower alkyl, substituted lower alkyl, and cycloalkyl provided however that when R1 is a substituted lower alkyl, then the substituent does not include an amino group;
- R2a is hydrogen;
- R2b is hydrogen;
- R3 is selected from the group consisting of hydrogen, halogen, lower alkyl, substituted lower alkyl, cycloalkyl and substituted cycloalkyl provided however that when R3 is a substituted lower alkyl, then the substituent does not include an amino group;
- R4 is selected from the group consisting of hydrogen, halogen, lower alkyl, substituted lower alkyl, cycloalkyl and substituted cycloalkyl provided however that when R4 is a substituted lower alkyl, then the substituent does not include an amino group.
Dependencies are inferred from the claim text.