Substituted pyrazolo [3,4-d]pyrimidines as cytokine modulators

A compound of formula

• wherein
• R1 is methyl,
• R2 is hydrogen,
• n is 0, 1 or 2,
• R3 is cyclopropyl,
• X1 is a single bond or alkylene,
• A, X2 and D are a pyrazolopyrimidine group of formula III
• k is an integer from 0 to 4,
• w is an integer from 0 to 4,
• R13 is hydrogen, alkyl, OH or NH2, and
• (CR9R10)wE is alkyl, alkoxy, halo, —CH2-heterocyclyl, —CONH-cycloalkyl, alkylsulfonyl, alkylthio, alkylsulfonylamino, haloalkyl, aminocarbonyl, pseudohalo or heterocyclyl, or two (CR9R10)wE groups, which substitute adjacent atoms on D, together form alkylenedioxy,
• wherein
• alkyl is lower alkyl having 1 to 6 carbon atoms,
• alkylene is lower alkylene having 1 to 6 carbons,
• haloalkyl is an alkyl group in which one or more of the hydrogen atoms are replaced by halogen
• cycloalkyl is to a saturated mono- or multicyclic ring system of 3 to 10 carbon atoms,
• alkoxy is RO—,
• alkylthio is RS—,
• R is lower alkyl having 1 to 6 carbon atoms
• pseudohalo is cyanide, cyanate, thiocyanate, selenocyanate, trifluoromethoxy, or azido and
• heterocyclyl is a monocyclic or multicyctic non-aromatic ring system of 3 to 10 members where 1 to 3, of the atoms in the ring system is a heteroatom selected from nitrogen, oxygen or sulfur or a pharmaceutically acceptable salt thereof.