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US 7,569,556 B2Granted
Method of use of carboxylated polysaccharides topically on the eyeball
AssigneeBoard of Trustees of Michigan State University
InventorsRamani Narayan, Laura M. Fisher
Life of this patent
Estimating the term…
Abstract
The use of chemically modified dicarboxy polysaccharides for the topical treatment of the eyeball are described. The modified polysaccharides provide a carrier in solutions for the treatment of the eyeball to obtain a timed release.
Claims18
A method for providing a topical timed release of a fluoroquinolone antibacterial agent for the eyeball of an animal in need thereof, the method comprising:
- (a) providing a composition comprising the fluoroquinolone antibacterial agent and a chemically modified polysaccharide (CMP) random copolymer, the CMP comprising
- (i) saccharide rings having C2 and C3 carbon positions and a bond therebetween, the saccharide rings being linked with
- (ii) ring-opened saccharide units at the bond between the C2 and C3 carbon positions, the ring-opened C2 and C3 carbon positions containing carboxylic acid moieties, water dispersible salts thereof, or combinations thereof;
- wherein the CMP is dispersed in water to form a clear solution as a time-release adjuvant for the fluoroquinolone antibacterial agent;
- and
- (b) topically providing the composition on the eyeball to provide the timed release.
3 more elements
A pharmaceutical composition for topical treatment of the eyeball, the composition comprising:
- (a) a fluoroquinolone antibacterial agent for the eyeball in need of a timed release;
- and
- (b) a chemically modified polysaccharide (CMP) random copolymer, the CMP comprising
- (i) saccharide rings having C2 and C3 carbon positions and a bond therebetween, the saccharide rings being linked with
- (ii) ring-opened saccharide units at the bond between the C2 and C3 carbon positions, the ring-opened C2 and C3 carbon positions containing carboxylic acid moieties, water dispersible salts thereof, or combinations thereof;
- wherein the CMP is water-dispersible to form a clear solution as a time-release adjuvant for the fluoroquinolone antibacterial agent.
3 more elements
A pharmaceutical composition for topical treatment of the eyeball, the composition comprising:
- (a) a fluoroquinolone antibacterial agent for the eyeball;
- and
- (b) a chemically modified polysaccharide starch (CMP) random copolymer, the CMP comprising
- (i) saccharide rings having C2 and C3 carbon positions and a bond therebetween, the saccharide rings being linked with
- (ii) ring-opened saccharide units at the bond between the C2 and C3 carbon positions, the ring-opened C2 and C3 carbon positions containing carboxylic acid moieties, water dispersible salts thereof, or combinations thereof;
- wherein the CMP is water-dispersible to form a clear solution as a time-release adjuvant for the fluoroquinolone antibacterial agent.
3 more elements
Dependencies are inferred from the claim text.