Methods for preparing 2-methoxyisobutylisonitrile and tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate
AssigneeDraximage Limited
InventorPierre Morel
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Abstract
The present invention relates to new synthetic methods for preparing 2-methoxyisobutylisonitrile and metal isonitrile complexes, such as tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluroroborate, which are used in the preparation of technetium (99mTc) Sestamibi, and novel intermediate compounds useful in such methods.
Claims2
A formulation including tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate, sodium citrate dihydrate, L-cysteine hydrochloride monohydrate, mannitol, and stannous chloride dihydrate under an inert gas in a lyophilized vial, wherein the tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate is sufficiently pure so that when the formulation is (i) reconstituted with sodium pertechnetate (99mTc) for injection in saline obtained from the elution of a 99Mo/99mTc generator and (ii) heated to form 99mTc-Sestamibi, the 99mTcSestamibi contains no quantifiable amount of 99mTc-pentamibi dimethylvinyl isonitrile.
Dependencies are inferred from the claim text.