Substance specific to human PD-1
AssigneesOno Pharmaceutical Co., Ltd., Tasuku Honjo
InventorsTasuku Honjo, Shiro Shibayama, Kazuhiko Takeda, Masayoshi Matsuo, Takao Yoshida, Masakazu Miyamoto
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Abstract
The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.
Claims4
A substantially pure polypeptide selected from the group consisting of (i) to (iii):
- (i) a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2;
- (ii) a polypeptide comprising the amino acid sequence of SEQ ID NO:4;
- (iii) a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 11.
A bispecific antibody, wherein the following parts are linked by peptide linkers in the following order, respectively:
- (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:2;
- (b) a polypeptide comprising the amino acid sequence of SEQ ID NO:8;
- (c) a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 6, and
- (d) a polypeptide comprising the amino acid sequence of SEQ ID NO:4,
- so that said parts (a) and (d) can bind to human PD-1 together and said parts (c) and (b) can bind to human TCR complex together.
Dependencies are inferred from the claim text.