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US 7,563,443 B2Granted
Monovalent anti-CD40L antibody polypeptides and compositions thereof
AssigneeDomantis Limited
InventorsSteven Grant, Haiqun Liu, Kevin Moulder
Life of this patent
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AssigneeDomantis Limited
InventorsSteven Grant, Haiqun Liu, Kevin Moulder
Estimating the term…
The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of CD40L. In one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD40L, preferably without substantially agonizing CD40 activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/CD40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual.
An isolated antibody single variable domain polypeptide which has an amino acid sequence at least 85% identical to a sequence selected from the group consisting of SEQ ID NOs 7-82, which antibody polypeptide specifically and monovalently binds CD40L.
An isolated antibody single variable domain polypeptide comprising the sequence of SEQ ID NO:
An isolated antibody single variable domain polypeptide comprising the sequence of SEQ ID NO:
An isolated antibody single variable domain polypeptide consisting of the sequence of SEQ ID NO:
An isolated antibody single variable domain polypeptide comprising the sequence of SEQ ID NO:
Dependencies are inferred from the claim text.