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US 7,557,238 B2Granted
Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
AssigneeBiocon Limited
InventorsSumithra Srinath, Tom Thomas Puthiaparampil, Sambasivam Ganesh
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Abstract
In one aspect, the present invention provides a novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate, a key intermediate for the preparation of HMG-CoA reductase inhibitor.
Claims3
A process for the preparation of a compound of Formula I:
- comprising removing the tert-butyl diphenyl silyl group of a compound of Formula II:
- wherein the compound of Formula II is obtained by treating a compound of Formula III:
- wherein Alk is a straight or branched C1-C6 alkyl, with a carbanion generated by the reaction of tert-butyl acetate with lithium diisopropylamide, and
- wherein the compound of Formula III is obtained from reacting a compound of Formula IV:
- wherein Alk is a straight or branched C1-C6 alkyl, with tert-butyl diphenyl silyl chloride.
2 more elements
A compound of Formula II:
A compound of Formula III:
- wherein Alk is a straight or branched C1-C6 alkyl.
Dependencies are inferred from the claim text.