Long-acting polypeptides and methods of producing same
AssigneeModigene Inc
InventorsFuad Fares, Udi Eyal Fima
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Abstract
A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a peptide-of-interest are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
Claims14
A polypeptide consisting of an hGH protein, a single chorionic gonadotrophin carboxy terminal peptide or a truncated single chorionic gonadotrophin carboxy terminal peptide attached to the amino terminus of said hGH polypeptide, and two chorionic gonadotrophin carboxy terminal peptides attached to the carboxy terminus of said hGH polypeptide.
A polypeptide consisting of an hGH polypeptide, a single chorionic gonadotrophin carboxy terminal peptide or a truncated single chorionic gonadotrophin carboxy terminal peptide attached to the amino terminus of said hGH polypeptide, and two chorionic gonadotrophin carboxy terminal peptides attached to the carboxy terminus of said hGH polypeptide, wherein at least one chorionic gonadotrophin carboxy terminal peptide is attached to said hGH polypeptide via a linker.
A polypeptide consisting of an hGH polypeptide, a single chorionic gonadotrophin carboxy terminal peptide or a truncated single chorionic gonadotrophin carboxy terminal peptide attached to the amino terminus of said hGH polypeptide, and two chorionic gonadotrophin carboxy terminal peptides attached to the carboxy terminus of said hGH polypeptide and a signal peptide attached to the amino terminus of said one chorionic gonadotrophin carboxy terminal peptide.
A method of improving a biological half life of an hGH polypeptide, comprising the step of attaching one chorionic gonadotrophin carboxy terminal peptide to the amino terminus of said hGH polypeptide and two chorionic gonadotrophin carboxy terminal peptides to the carboxy terminus of said hGH polypeptide, thereby improving the biological half life of the hGH polypeptide.
Dependencies are inferred from the claim text.