Long-acting EPO polypeptides and derivatives thereof and methods thereof
AssigneeModigene Inc
InventorsFuad Fares, Udi Eyal Fima
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Abstract
A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to an EPO peptide are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
Claims14
A polypeptide consisting of an EPO polypeptide, one chorionic gonadotrophin carboxy terminal peptide attached to the amino terminus of said EPO polypeptide, and two chorionic gonadotrophin carboxy terminal peptides attached to the carboxy terminus of said EPO polypeptide.
A polypeptide consisting of an EPO polypeptide, one chorionic gonadotrophin carboxy terminal peptide attached to the amino terminus of said EPO polypeptide, and two chorionic gonadotrophin carboxy terminal peptides attached to the carboxy terminus of said EPO polypeptide wherein at least one chorionic gonadotrophin carboxy terminal peptide is attached to said EPO polypeptide via a linker.
A polypeptide consisting of an EPO polypeptide, one chorionic gonadotrophin carboxy terminal peptide attached to the amino terminus of said EPO polypeptide, two chorionic gonadotrophin carboxy terminal peptides attached to the carboxy terminus of said EPO polypeptide, and a signal peptide attached to the amino terminus of said one chorionic gonadotrophin carboxy terminal peptide.
A method of improving a biological half life of an EPO polypeptide, comprising the step of attaching one chorionic gonadotrophin carboxy terminal peptide to the amino terminus of said EPO polypeptide and two chorionic gonadotrophin carboxy terminal peptides to the carboxy terminus of said EPO polypeptide, thereby improving the biological half life of the EPO polypeptide.
Dependencies are inferred from the claim text.