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US 7,553,816 B2Granted
p-amidobenzylethers in drug delivery agents
AssigneeSeattle Genetics, Inc.
InventorsPeter D. Senter, Brian E. Toki, Scott Jeffrey
Life of this patent
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Abstract
Compounds of the formulas LAn-Z-X—WwD and BZ-X—WwD wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and/or excipient, and methods of delivery the drug D via the compounds.
Claims51
A compound of the formula:
- LAn-Z-X—WwD
- wherein:
- D is a drug moiety;
- L is a ligand;
- A is an optional acyl unit;
- Z is an amino acid or a peptide;
- X is an aminobenzyl ether self-immolative group;
- W is an optional second self-immolative group;
- n is an integer of 0 or 1;
- w is an integer of 0 or 1;
- and
- wherein X forms an ether linkage with W when w is 1 or with D when w is 0.
9 more elements
Dependencies are inferred from the claim text.