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US 7,553,810 B2Granted
Lung volume reduction using glue composition
AssigneePneumRx, Inc.
InventorsGlen Gong, Ronald Dieck
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.
Claims36
A method of reducing lung volume in a subject comprising:
- providing a glue composition comprising a cross-linking moiety of a heat stabilized glutaraldehyde, a pharmaceutically acceptable carrier, an adhering moiety, and a cross-linkable moiety of an albumin, wherein the cross-linkable moiety is covalently linked to the cross-linking moiety, and wherein the adhering moiety is coupled to the cross-linkable moiety and is a member selected from the group consisting of alpha-1 antitrypsin, elafin, and a serpin;
- administering an effective amount of said glue composition to a localized region of damaged lung tissue of said subject;
- collapsing a first portion or all of the lung of said subject wherein said first portion comprises said localized region of damaged lung tissue;
- allowing said adhering moiety to bind to different sites of lung tissue;
- and
- re-inflating a second portion of the lung of said subject wherein said second portion does not comprise said damaged lung tissue, thereby reducing lung volume.
3 more elements
A method of treating a pulmonary condition comprising:
- providing a glue composition comprising a cross-linking moiety of a heat stabilized glutaraldehyde, a cross-linkable moiety of an albumin, and an adhering moiety, wherein the adhering moiety adheres in less than 3 hours, wherein the cross-linkable moiety is covalently linked to the cross-linking moiety, and wherein the adhering moiety is coupled to the cross-linkable moiety and is a member selected from the group consisting of alpha-1 antitrypsin, elafin, and a serpin;
- administering an effective amount of said glue composition to a localized region of damaged lung tissue of a subject;
- collapsing a first portion or all of the lung of said subject wherein said first portion comprises said localized region of damaged lung tissue;
- allowing said adhering moiety to adhere different sites of lung tissue;
- and
- re-inflating a second portion of the lung of said subject wherein said second portion does not comprise said damaged lung tissue, thereby reducing lung volume.
3 more elements
A method of treating a damaged lung of a subject, comprising:
- administering an effective amount of a glue composition to a localized region of damaged lung tissue of the subject, wherein the glue composition comprises an adhering moiety, albumin and a heat stabilized glutaraldehyde, wherein the albumin is covalently linked to the heat stabilized glutaraldehyde, and wherein the adhering moiety is coupled to albumin and is a member selected from the group consisting of alpha-1 antitrypsin, elafin, and a serpin;
- collapsing a first portion or all of the lung of the subject, wherein the first portion comprises the localized region of damaged lung tissue;
- and
- re-inflating a second portion of the lung of the subject, wherein the second portion does not comprise at least a portion of the damaged lung tissue, thereby treating the damaged lung.
1 more element
A method of treating a damaged lung of a subject, comprising:
- administering an effective amount of a composition to a localized region of damaged lung tissue of the subject, wherein the composition comprises a first adhering moiety coupled with a first albumin and a second adhering moiety coupled with a second albumin, wherein each of the first and second adhering moieties is a member selected from the group consisting of alpha-1 antitrypsin, elafin, and a serpin;
- collapsing a first portion or all of the lung of the subject, wherein the first portion comprises the localized region of damaged lung tissue;
- administering an effective amount of a cross-linking activating moiety of a heat stabilized glutaraldehyde to the localized region of damaged lung tissue of the subject, so as to cross-link the first albumin with the second albumin;
- and
- re-inflating a second portion of the lung of the subject, wherein the second portion does not comprise at least a portion of the damaged lung tissue, thereby treating the damaged lung.
2 more elements
Dependencies are inferred from the claim text.