High strength biological cement composition and using the same
AssigneeInnovative BioCeramix, Inc.
InventorsDonghui Lu, Shuxin Zhou
Life of this patent
Estimating the term…
Abstract
A hydraulic cement for biomedical applications. The cement sets in-situ, hardening when exposed to water to produce nano-dispersed composite of calcium-silicate-hydrate gel mixed with hydroxyapatite. In comparison with prior cements, the composition provides high biocompatibility, high bioactivity and high biomechanical strength, due to the composite structure of the calcium silicate hydrate reinforced with co-precipitated particles of hydroxyapatite. Biocompatibility is also increased due to an absence of aluminum and magnesium in the composition. The cement is suitable for variety of applications, including dental implants, bone fixation, and bone repair.
Claims18
A bio-active and biocompatible hydraulic cement composition for medical and dental applications that reacts with water at a substantially neutral pH, said hydraulic cement composition comprising:
- at least one calcium silicate compound that produces calcium silicate hydrate-gel and calcium hydroxide during hydration when water is added to said composition at near neutral pH, said at least one calcium silicate compound being selected from the group consisting of:
- di-calcium silicate;
- tri-calcium silicate;
- tetra-calcium silicate;
- and
- combinations thereof;
- and
- calcium phosphate monobasic that reacts with said calcium hydroxide that is produced by hydration of said at least one calcium silicate compound to produce hydroxyapatite in-situ during setting of said composition;
- said hydraulic cement composition being substantially free of both aluminum and magnesium.
A method for treatment of medical or dental conditions using a hydraulic cement that reacts with water at a substantially neutral pH, said method comprising the steps of:
- providing a bioactive and biocompatible hydraulic cement comprising:
- water at a substantially neutral pH;
- at least one calcium silicate compound that produces calcium silicate hydrate gel and calcium hydroxide during hydration with said water, said at least one calcium silicate compound being selected the group consisting of:
- di-calcium silicate;
- tri-calcium silicate;
- tetra-calcium silicate;
- and
- combinations thereof;
- and
- calcium phosphate monobasic, that reacts with said calcium hydroxide that is produced by hydration of said at least one calcium silicate compound, to produce in-situ at least one calcium phosphate compound during setting of said cement;
- said hydraulic cement being substantially free of both aluminum and magnesium;
- depositing said hydraulic cement in a selected location in the body of a patient;
- and
- allowing said hydraulic cement to cure to solid in said selected location in the body of said patient.
Dependencies are inferred from the claim text.