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US 7,550,497 B2Granted
Phosphoramide derivatives
AssigneePalau Pharma, S.A.
InventorsCarmen Almansa Rosales, Javier Bartroli Orpi
Life of this patent
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Abstract
New phosphoramide derivatives of formula (I) and the salts and solvates thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful as antiinflammatory and analgesic agents.
Claims18
A compound of general formula I:
- wherein:
- each R1 independently represents hydrogen, C1-6 alkyl, C1-6 haloalkyl, phenyl, heteroaryl or phenylC1-3 alkyl, where all phenyl and heteroaryl rings can be optionally substituted with one or more halogen, C1-4 alkyl or C1-4 alkoxy groups, or both substituents R1 may be taken together to form a saturated or partially unsaturated 5- or 6-membered ring, which can be optionally fused to a benzene ring;
- A represents an imidazole, pyrazole, isoxazole or oxazole, where the substituents L and D are placed on adjacent atoms of ring A, and where additionally A can be optionally substituted with one or more substituents R2;
- L represents a single bond, —O—, —S— or —NR3—;
- B represents C1-6 alkyl or a ring selected from phenyl, heteroaryl and C3-7 cycloalkyl, where all said rings can be optionally substituted with one or more substituents R4;
- D represents phenyl or pyridine, each of which can be optionally substituted with one or more halogens;
- the groups A and —SO2NHP(O) (OR1)2 are placed on ring D in para position with respect to one another;
- each R2 independently represents halogen, cyano, nitro, carboxy, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, hydroxy, C1-4 hydroxyalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio, amino, C1-4 alkylamino, C1-4 dialkylamino, formyl, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-4 haloalkoxycarbonyl, C1-4 alkoxyC1-3 alkyl, C1-4 alkylcarbonyloxyC1-3 alkyl, C3-7 cycloalkylC1-4 alkoxyC1-3 alkyl or C3-7 cycloalkoxyC1-3 alkyl, or two substituents R2 on the same carbon atom can be taken together to form an oxo group;
- R3 represents hydrogen or C1-4 alkyl;
- each R4 independently represents halogen, cyano, nitro, carboxy, C1-4 alkyl, C1-4 haloalkyl, hydroxy, C1-4 hydroxyalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio, amino, C1-4 alkylamino, C1-4 dialkylamino, formyl, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl or C1-4 haloalkoxycarbonyl, or two substituents R4 on the same carbon atom can be taken together to form an oxo group, and additionally one of the substituents R4 can represent a saturated, unsaturated or partially unsaturated 5- or 6-membered ring which can optionally contain from 1 to 3 heteroatoms selected from N, O and S and which can be optionally substituted with one or more substituents R5;
- each R5 independently represents halogen, hydroxy, nitro, cyano, amino, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy or C1-4 alkylcarbonyl, or two substituents R5 on the same carbon atom can be taken together to form an oxo group;
- and
- heteroaryl in the above definitions represents pyridine, pyrazine, pyrimidine or pyridazine;
- or a salt thereof.
11 more elements
Dependencies are inferred from the claim text.