8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation thereof and their use as pharmaceutical composition

A compound of formula

• wherein
• R1 is
• (a) a heteroaryl-C1-3-alkyl group,
• wherein heteroaryl is selected from the group consisting of phenylpyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, naphthyridinyl and phenanthridinyl which may be optionally substituted by R10, R11 and R12,
• where R10 is selected from hydrogen, fluorine, chlorine, bromine, methyl, difluoromethyl, trifluoromethyl, phenyl, cyano, methoxy, difluoromethoxy, trifluoromethoxy, amino, methylamino, dimethylamino, pyrrolidin-1-yl, piperidin-1-yl or morpholin-4-yl group;
• R11 is selected from hydrogen, methyl, methoxy or cyano;
• and
• R12 is hydrogen or methyl,
• or
• (b) a naphthyl-C1-3-alkyl group, which may be substituted by R13 and R14,
• where R13 is selected from hydrogen, fluorine, chlorine, bromine methyl, difluoromethyl,
• trifluoromethyl, cyano, methoxy, difluoromethoxy or trifluoromethoxy;
• and
• R14 is selected from hydrogen, methyl, methoxy or cyano;
• R2 is selected from methyl, ethyl, propyl, isopropyl, cyclopropyl or phenyl;
• R3 is selected from 2-butyn-1-yl, 1-buten-1-yl, 2-buten-1-yl or 3-methyl-2-buten-1-yl and
• n is 1 or 2;
• or a tautomer, enantiomer, diastereomer, mixture, prodrug or salt thereof.