Controlled release polymer nanoparticle containing bound nucleic acid ligand for targeting
AssigneeMassachusetts Institute of Technology
InventorsOmid C. Farokhzad, Sangyong Jon, Robert S. Langer
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Abstract
The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer system includes an agent such as a therapeutic, diagnostic, prognostic, or prophylactic agent. The nucleic acid ligand that is bound to the controlled release polymer system, binds selectively to a target, such as a cell surface antigen, and thereby delivers the controlled release polymer system to the target.
Claims37
A controlled release polymer nanoparticle, comprising;
- a therapeutic or diagnostic agent incorporated in the controlled release polymer nanoparticle;
- and
- a nucleic acid ligand comprising an oligonucleotide bound to the surface of the controlled release polymer nanoparticle that selectively binds to a target cell or tissue, and thereby delivers the controlled release polymer nanoparticle to the target cell or tissue;
- wherein the controlled release polymer nanoparticle carries a neutral to negative charge on its surface;
- and
- wherein the bound oligonucleotide has a folded three-dimensional conformation resulting from intramolecular interactions.
Dependencies are inferred from the claim text.