Antibody to the human OX40 receptor
AssigneeCrucell Holland B.V.
InventorsAlexander Berthold Hendrik Bakker, Pauline Marie Louise Meester-Rood, Adrianus Quirinus Bakker
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Abstract
The present invention provides binding molecules, such as human binding molecules, that bind to and stimulate the human OX40-receptor. The invention also provides nucleic acids encoding such binding molecules. Methods for producing such binding molecules are also provided by the present invention. The binding molecules and nucleic acids are useful in the stimulation of human T-cells and can be used to enhance antigen-specific immune responses.
Claims8
A human antibody able to bind to the human OX40 receptor, wherein the antibody comprises
- a heavy chain variable region comprising the variable region of amino acid sequence SEQ ID NO:27, or a sequence that is at least 97% homologous thereto, and
- wherein the human antibody comprises a light chain variable region comprising the variable region of amino acid sequence of SEQ ID NO:
- 31, or a sequence that is at least 97% homologous thereto.
A human antibody capable of binding to the human OX40 receptor, comprising a heavy chain comprising amino acid sequence SEQ ID NO:27, and a light chain comprising amino acid sequence of SEQ ID NO:
- 31.
Dependencies are inferred from the claim text.