Irritation-reducing ocular iontophoresis device
AssigneeEyegate Pharma S.A.S.
InventorPierre Roy
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Abstract
The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.
Claims24
An ocular iontophoresis device for transporting medication across a biological membrane of the eye, the device comprising:
- a medication reservoir configured to store at least one medication in solution, the reservoir suitable for being positioned on the eye,
- an active electrode disposed in the reservoir, the active electrode arranged so as to receive an electric field suitable for polarizing it to electrolyze when stored therein the at least one medication in a solution containing few or no ions competing with the at least one medication, and
- a passive electrode also polarizable by the external electrical source,
- the at least one medication being transported efficiently across the biological membrane of the eye through iontophoresis induced by the active and passive electrode.
A method of transporting medication across a biological membrane of the eye comprising:
- positioning an iontophoresis device on the biological membrane of the eye, the device comprising a reservoir, an active electrode placed in the reservoir, and a passive electrode, the medication in solution having a pH within the range of about 4.5 to about 11.5 and including an active principle, which is associated with an additive and having an ionic form of valency greater than or equal to 1;
- and
- polarizing the active electrode with respect to the passive electrode,
- wherein polarization of the electrodes with respect to each other transports medication across the biological membrane of the eye through ocular iontophoresis.
Dependencies are inferred from the claim text.