Compositions useful as inhibitors of protein kinases

A pharmaceutical composition comprising a compound of formula I:

• or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle, wherein:
• R1 is Ar1;
• R2 is hydrogen;
• T is CH;
• A1 is C-halogen, C—CN, or C—R;
• each of A2 and A3 is, independently, CR4;
• R4 is selected from halogen, NO2, CN, -(L)mR, -(L)mAr1, or -(L)mCy1;
• or
• two R4 groups on adjacent atoms are taken together to form an optionally substituted 5-7 membered partially unsaturated or fully unsaturated ring having 0-3 heteroatoms independently selected from oxygen, sulfur, or nitrogen, wherein each ring formed by two R4 groups on adjacent atoms taken together is optionally substituted with up to 4 occurrences of Z—RX;
• L is a C1-6 alkylidene chain wherein one methylene unit of L is optionally replaced by —O—, —N(R)—, —N(R)C(O)—, —C(O)—, —C(O)N(R)—, —SO2N(R)—, or —N(R)SO2—;
• m is 0 or 1;
• Ar1 is
• Cy1 is selected from
• wherein;
• Ar1 and Cy1 are each optionally substituted with up to 5 occurrences of Z-RX;
• wherein
• each occurrence of Z is independently a bond or a C1-6 alkylidene chain, wherein up to two non-adjacent methylene units of Z are optionally replaced by —S—, —O—, —N(R)—, —N(R)C(O)—, —C(O)N(R)—, —SO2N(R)—, or —N(R)SO2—;
• each occurrence of RX is independently selected from —R′, halogen, NO2, CN, —OR′, —SR′, or —N(R′)2,
• each occurrence of R is independently hydrogen or a C1-6 aliphatic group;
• and
• each occurrence of R′ is independently hydrogen, a C1-6 aliphatic group, a C6-10 aryl ring, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 3-10 ring atoms;
• or
• R and R′ or two occurrences of either R or R′ are taken together with the atoms to which they are bound to form an optionally substituted 5-8 membered saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• or
• two occurrences of either R′ or R on the same nitrogen are taken together with the nitrogen atom to which they are bound to form an optionally substituted 5-8 membered saturated, partially unsaturated, or aryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur.