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US 7,547,788 B2Granted
Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AssigneeNeuroSearch A/S
InventorsDan Peters, Gunnar M. Olsen, Elsebet Østergaard Nielsen, Jørgen Scheel-Krüger, Birgitte L. Eriksen
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Abstract
This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Claims6
A piperidine derivative of the Formula I:
- any of its stereoisomers or any mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof,
- wherein
- Ra represents hydrogen or alkyl;
- X represents —O—;
- Rb represents a phenyl group, which phenyl group is substituted with one or more substituents independently selected from the group consisting of:
- halo, trifluoromethyl, trifluoromethoxy, cyano and alkoxy;
- each of R2, R2′, R6 and R6′represents alkyl;
- and
- each of R3, R3′, R5 and R5′represents hydrogen.
6 more elements
Dependencies are inferred from the claim text.