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US 7,547,787 B2Granted
Processes for preparing montelukast sodium
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsEvgeny Shapiro, Ronit Yahalomi, Valerie Niddam-Hildesheim, Greta Sterimbaum, Kobi Chen
Life of this patent
Estimating the term…
Abstract
The present invention provides processes for preparing montelukast.
Claims27
A process for preparing an ester of montelukast comprising the following steps:
- a) activating 2-(2-(3(S)-(3-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-((α-hydroxy)propyl)phenyl-2-propanol with a benzylsulfonyl or mesyl group;
- and
- b) reacting the product of step (a) with 1-(mercaptomethyl)cyclopropaneacetic acid alkyl ester in a solvent and in the presence of a cosolvent and a base to obtain an ester of montelukast.
Dependencies are inferred from the claim text.