US 7,547,782 B2Granted

Met kinase inhibitors

AssigneeBristol-Myers Squibb Company

InventorsRobert M. Borzilleri, Xiao-Tao Chen, David K. Williams, John S. Tokarski, Robert F. Kaltenbach

Life of this patent

Estimating the term…

Abstract

The present invention is directed to compounds having the formula I or II: including salts thereof, and methods for using them for the treatment of cancer.

Claims17

Dependent claims

A compound having the following Formula I or Formula II:

or a salt thereof:
wherein
each R1 is H, halogen, halogenated alkyl, cyano, NO2, OR6, NR7R8, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl;
B is O, NR9, S, SO, SO2, or CR10R11;
W and X are each CH;
V is CO;
n is 1 to 4;
m is 1 to 4;
p is 0 to 2;
l is 1 to 2;
R2 is H, alkyl, substituted alkyl, cycloalkyl, or substituted cycloalkyl;
R3 and R4 are independently H, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl, or taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms;
R5 is —NR12R13, —OR14, alkyl, substituted alkyl, haloalkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl;
R6, R7, R8, and R9 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl or substituted heterocycloalkyl;
R10 and R11 are each independently H, halogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, benzyl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl, or taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms;
R12 and R13 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, arylalkyl, substituted arylalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, or substituted heterocycloalkyl, or taken together to form a heterocyclic ring of 3 to 8 atoms;
wherein
G is O, S, or NR106;
D is CR107 or N;
Z is N or CR108;
Q is an optionally substituted carbocyclic or heterocyclic ring containing 4-8 atoms;
R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R34, R35, R37, R38, R39, R40, R41, R42, R43, R44, R45, R46, R47, R48, R49, R50, R51, R52, R53, R54, R55, R56, R57, R58, R59, R60, R61, R62, R63, R64, R65, R66, R67, R68, R69, R70, R71, R72, R73, R74, R75, R76, R77, R78, R79, R80, R81, R82, R84, R86, R87, R88, R89, R90, R91, R92, R93, R94, R95, R96, R97, R98, R99, R102, R103, R104, R105, R107 and R108 are each independently H, halogen, haloalkyl, NO2, cyano, OR109, NR110R111, CO2R112, C(O)NR113R114, SO2R115, SO2NR116R117, NR118SO2R119, NR120C(O)R121, NR122CO2R123, —CO(CH2)mR124;
-CONH(CH2)mR125, SR126, SOR127 aminoalkyl, alkylaminoalkyl, alkylaminoalkylamino, diaalkylaminoalkylamino, alkylaminoalkynyl, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C7 cycloalkyl, substituted C3 to C7 cycloalkyl, alkenyl, substituted alkenyl, alkenylalkyl, substituted alkenylalkyl, alkynyl, substituted alkynyl, hydroxyalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl;
or
R40 is taken together with either R39 or R41 to form a carbocyclic, or an unsaturated or saturated heterocyclic ring of 3 to 8 atoms;
R32, R33, R83 , and R85 are each independently H, halogenated alkyl, —CO2R128, —SO2R129, —CO(CH2)mR130, alkylaminoalkyl, alkylaminoalkynyl, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C7 cycloalkyl, substituted C3 to C7 cycloalkyl, hydroxyalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, or heterocycloalkyl;
R100 and R101 are independently selected from H, halogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl, or taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms;
and
R14, R106, R109, R110, R111, R112, R113, R114, R115, R116, R117, R118, R119, R120, R121, R122, R123, R124, R125, R126, R127, R128, R129 and R130 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl.

26 more elements

The compound having the following Formula I:

or a salt thereof wherein:
each R1 is H, halogen, halogenated alkyl, cyano, NO2, OR6, NR7R8, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl;
B is O, NR9, S, SO, SO2, or CR10R11;
W and X are each CH;
V is CO;
n is 1 to 4;
m is 1 to 4;
p is 0 to 2;
l is 1 to 2;
R2 is H, alkyl, substituted alkyl, cycloalkyl, or substituted cycloalkyl;
R3 and R4 are independently H, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl or taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms;
R5 is —NR12R13, —OR14, alkyl, substituted alkyl, haloalkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl;
R6, R7, R8, and R9 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl;
R10 and R11 are each independently H, halogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl, or taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms;
R12 and R13 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, arylalkyl, substituted arylalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, or substituted heterocycloalkyl, or taken together to form a heterocyclic ring of 3 to 8 atoms;
wherein
R16, R17, R18, R19, R20, R22, R24, R50, R51, R52, R55, R56, R57R58, and R59 are each independently, H, halogen, halogenated alkyl, NO2, cyano, OR109, NR110OR111, CO2R112, C(O)NR113R114, SO2R115, SO2NR116R117, NR118SO2R119, NR120C(O)R121, NR122CO2R123, —CO(CH2)mR124;
—CONH(CH2)mR125, SR126, SOR127, alkylaminoalkyl, alkylaminoalkynyl, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C7 cycloalkyl, substituted C3 to C7 cycloalkyl, alkenyl, substituted alkenyl, alkenylalkyl, substituted alkenylalkyl, alkynyl, substituted alkynyl, hydroxyalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl;
and
R14, R106, R109, R110, R111, R112, R113, R114, R115, R116, R117, R118, R119, R120, R121, R122, R123, R124, R125, R126, and R127, are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl.

17 more elements

A compound selected from group consisting of:

4-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide, hydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide, hydrochloride salt;
2-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide, hydrochloride salt;
2-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(4-chlorophenyl)nicotinamide, dihydrochloride salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide, dihydrochloride salt;
2-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-benzylnicotinamide, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-benzylnicotinamide, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-o-tolylnicotinamide, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluoro-2-methylphenyl)nicotinamide, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2-chlorophenyl)nicotinamide, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorobenzyl)nicotinamide, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2-morpholino-1-phenylethyl)nicotinamide, trihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2-(2-hydroxyethyl)phenyl)nicotinamide, bis(trifluoroacetic acid) salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(5-fluoropyridin-2-yl)nicotinamide, bis(trifluoroacetic acid) salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-4-methoxynicotinamide, bis(triflouroacetic acid) salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridine-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-4-hydroxynicotinamide, bis(trifluoroacetic acid) salt;
2-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-5-bromo-N-(2,4-difluorophenyl)nicotinamide, bis(trifluoroacetic acid) salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-5-bromo-N-(2,4-difluorophenyl)nicotinamide, dihydrochloride salt;
2-(4-(2-Amino-3-(hydroxymethyl)pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)-N-methylnicotinamide, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-6-methylnicotinamide, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)pyridin-3-yl)(5-fluoroindolin-1-yl)methanone, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)nicotinamide, bis(trifluoroacetic acid) salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-methylnicotinamide, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-5-chloro-N-methylnicotinamide, dihydrochloride salt;
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)nicotinamide, bis(trifluoroacetic acid) salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-(methylthio)pyrimidine-5-carboxamide, bis(trifluoroacetic acid) salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-(trifluoromethyl)pyrimidine-5-carboxamide, dihydrochloride salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-2-cyano-N-(2,4-difluorophenyl)pyrimidine-5-carboxamide, dihydrochloride salt;
2-(Aminomethyl)-4-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)pyrimidine-5-carboxamide, trihydrochloride salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-morpholinopyrimidine-5-carboxamide, trihydrochloride salt;
2-Amino-4-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)pyrimidine-5-carboxamide, trihydrochloride salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-(methylamino)pyrimidine-5-carboxamide, trihydrochloride salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-(dimethylamino)pyrimidine-5-carboxamide, trihydrochloride salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-(2-(dimethylamino)ethylamino)pyrimidine-5-carboxamide, trihydrochloride salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-(piperidin-1-yl)pyrimidine-5-carboxamide, trihydrochloride salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-2-(benzylamino)-N-(2,4-difluorophenyl)pyrimidine-5-carboxamide, trihydrochloride salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)pyrimidine-5-carboxamide, bis(trifluoroacetic acid) salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-methoxypyrimidine-5-carboxamide, dihydrochloride salt;
4-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)-2-hydroxypyrimidine-5-carboxamide, dihydrochloride salt;
3-(4-(2-Aminopyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)pyrazine-2-carboxamide, bis(trifluoroacetic acid) salt;
and
3-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)pyrazine-2-carboxamide bis(trifluoroacetic acid) salt.

40 more elements

Dependencies are inferred from the claim text.

Facts

Application: 11/529,875Filed 28 Sep 2006 · us provisional application
Priority: 30 Sep 2005
Published: US 2007/0078140 A15 Apr 2007
Granted: 16 Jun 2009
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07D 401/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
A61P 35/00
Antineoplastic agents
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
C07D 213/82
Amides; Imides: in position 3

Family

Application60/722,089Us provisional application · filed 30 Sep 2005
US 2007/0078140 A1Pre-grant publication · published 5 Apr 2007
US 7,547,782 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

The present invention is directed to compounds having the formula I or II: including salts thereof, and methods for using them for the treatment of cancer.

A compound having the following Formula I or Formula II:

or a salt thereof:
wherein
each R1 is H, halogen, halogenated alkyl, cyano, NO2, OR6, NR7R8, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl;
B is O, NR9, S, SO, SO2, or CR10R11;
W and X are each CH;
V is CO;
n is 1 to 4;
m is 1 to 4;
p is 0 to 2;
l is 1 to 2;
R2 is H, alkyl, substituted alkyl, cycloalkyl, or substituted cycloalkyl;
R3 and R4 are independently H, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl, or taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms;
R5 is —NR12R13, —OR14, alkyl, substituted alkyl, haloalkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl;
R6, R7, R8, and R9 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl or substituted heterocycloalkyl;
R10 and R11 are each independently H, halogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, benzyl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl, or taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms;
R12 and R13 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, arylalkyl, substituted arylalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycloalkyl, or substituted heterocycloalkyl, or taken together to form a heterocyclic ring of 3 to 8 atoms;
wherein
G is O, S, or NR106;
D is CR107 or N;
Z is N or CR108;
Q is an optionally substituted carbocyclic or heterocyclic ring containing 4-8 atoms;
R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R34, R35, R37, R38, R39, R40, R41, R42, R43, R44, R45, R46, R47, R48, R49, R50, R51, R52, R53, R54, R55, R56, R57, R58, R59, R60, R61, R62, R63, R64, R65, R66, R67, R68, R69, R70, R71, R72, R73, R74, R75, R76, R77, R78, R79, R80, R81, R82, R84, R86, R87, R88, R89, R90, R91, R92, R93, R94, R95, R96, R97, R98, R99, R102, R103, R104, R105, R107 and R108 are each independently H, halogen, haloalkyl, NO2, cyano, OR109, NR110R111, CO2R112, C(O)NR113R114, SO2R115, SO2NR116R117, NR118SO2R119, NR120C(O)R121, NR122CO2R123, —CO(CH2)mR124;
-CONH(CH2)mR125, SR126, SOR127 aminoalkyl, alkylaminoalkyl, alkylaminoalkylamino, diaalkylaminoalkylamino, alkylaminoalkynyl, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C7 cycloalkyl, substituted C3 to C7 cycloalkyl, alkenyl, substituted alkenyl, alkenylalkyl, substituted alkenylalkyl, alkynyl, substituted alkynyl, hydroxyalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heterocycloalkyl, or substituted heterocycloalkyl;
or
R40 is taken together with either R39 or R41 to form a carbocyclic, or an unsaturated or saturated heterocyclic ring of 3 to 8 atoms;
R32, R33, R83 , and R85 are each independently H, halogenated alkyl, —CO2R128, —SO2R129, —CO(CH2)mR130, alkylaminoalkyl, alkylaminoalkynyl, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C7 cycloalkyl, substituted C3 to C7 cycloalkyl, hydroxyalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, or heterocycloalkyl;
R100 and R101 are independently selected from H, halogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl, or taken together to form a carbocyclic or heterocyclic ring of 3 to 8 atoms;
and
R14, R106, R109, R110, R111, R112, R113, R114, R115, R116, R117, R118, R119, R120, R121, R122, R123, R124, R125, R126, R127, R128, R129 and R130 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heterocycloalkyl, or substituted heterocycloalkyl.

26 more elements

Facts

Application

11/529,875Filed 28 Sep 2006 · us provisional application

Priority

30 Sep 2005

Published

US 2007/0078140 A15 Apr 2007

Granted

16 Jun 2009

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07D 401/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
A61P 35/00
Antineoplastic agents
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
C07D 213/82
Amides; Imides: in position 3