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US 7,547,780 B2Granted
Dihydropteridione intermediate compounds
AssigneeBoehringer Ingelheim International GmbH
InventorsMatthias Grauert, Matthias Hoffman, Christian Eickmeier
Life of this patent
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Abstract
Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
Claims1
A compound of the formula (A5)
- R1 and R2, which may be identical or different, denote hydrogen, or a group selected from among C1-C6-alkyl, C2-C6-alkenyl and C2-C6-alkynyl, which may optionally be mono- or polysubstituted by one or more groups R9, or
- R1 and R2 together denote C2-C6-alkylene, in which optionally one or two methylene groups may be replaced by one of the groups —O or —NR7, and which may optionally be mono- or polysubstituted by one or more groups R9;
- R3 denotes hydrogen or a group selected from C1-C8-alkyl, C2-C8-alkenyl, C2-C8-alkynyl, C3-C8-cycloalkyl and C6-C14-aryl, which may optionally be mono- or polysubstituted by one or more groups R9;
- or
- R7 denotes hydrogen or C1-C6-alkyl,
- R9 denotes halogen, C1-C4-alkyl, C1-C4-alkyloxy, CN, OH or CF3;
- optionally in the form of the tautomers, racemates, enantiomers, diastereomers and mixtures thereof, and optionally in the form of the acid addition salts thereof.
4 more elements
Dependencies are inferred from the claim text.