Immunomodulatory constructs and their uses
AssigneeAuckland Uniservices Limited
InventorJohn David Fraser
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Abstract
The invention relates to immunomodulators. In particular the invention relates to specific immunomodulators based on the superantigen SMEZ-2 and more particularly based on mutants of the superantigen SMEZ-2, which are adapted to target antigen-presenting-cells for the purpose of enhancing or suppressing a host immune response.
Claims19
A construct which comprises an antigen-presenting-cell (APC) targeting molecule coupled to an antigen, wherein said APC targeting molecule contains a mutant of superantigen SMEZ-2 having the amino acid sequence of SEQ ID NO:1, wherein the mutant has a mutation at one or more positions of 18, 42, 75, and 182 in SEQ ID NO:1 and wherein the construct can bind to Class II MHC molecules.
A construct prepared by:
- a. introducing a mutation at one or more positions of 18, 42, 75, and 182 in SEQ ID NO:1 to produce a mutant of superantigen SMEZ-2, and
- b. coupling the mutant of SMEZ-2 with an antigen.
A superantigen, which has the amino acid sequence of SEQ ID NO:1 but for a mutation at one or more positions of 18, 42, 75 and 182 in SEQ ID NO:1.
A superantigen SMEZ-2 having the amino acid sequence of SEQ ID NO:2.
A superantigen SMEZ-2 having the amino acid sequence of SEQ ID NO:3.
Dependencies are inferred from the claim text.