Formamide derivatives for the treatment of diseases

A method of treating a disease in a mammal, said method comprising administering to said mammal in need of said treatment a therapeutically effective amount of a compound of formula (1),

• or a pharmaceutically acceptable salt thereof,
• wherein the (CH2)n—C(═O)Q1 group is in the meta or para position;
• —R1 and R2 are independently H or C1-C4 alkyl;
• —n is 0, 1 or 2;
• -Q1 is
• said group being optionally bridged by one carbon atom;
• *—NR8-Q2-A;
• p is 1 or 2;
• q is 1 or 2;
• Q2 is C1-C4 alkylene;
• R8 is H or C1-C4 alkyl;
• A is pyridyl;
• C3-C10 cycloalkyl, 2 or 3 carbon atoms of said cycloalkyl being optionally bridged by 1, 2, 3 or 4 C1-C4 alkyl, said alkylene bridge being optionally branched;
• tetrahydropyranyl;
• piperidinyl;
• tetrahydrothiopyranyl;
• —R3, R4, R5, R6 and R7 are independently H, C1-C4 alkyl, OR9, SR9, SOR9, SO2R9, halo, CO2R9, CF3, CN, OCF3, SO2NR9R10, CONR9R10, NR9R10, NHCOR10 or phenyl optionally substituted with 1 to 3 OR9, halo or C1-C4 alkyl;
• —R9 and R10 are independently H or C1-C4 alkyl;
• and
• the * represents the attachment point to the carbonyl group,
• or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising said compound of formula (1) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient or additive wherein said disease is selected from the group consisting of:
• asthma and chronic obstructive pulmonary disease.