Treating muscle wasting with selective androgen receptor modulators

A method of treating or reducing muscle loss in a subject suffering from a muscle wasting disorder, comprising the step of administering to said subject a selective androgen receptor modulator (SARM) compound of formula (I):

• wherein G is O or S;
• X is O;
• Z is NO2, CN, COOH, COR, NHCOR or CONHR;
• Y is CF3, F, I, Br, Cl, CN, C(R)3 or Sn(R)3;
• Q is halogen, CN, NHCOCH3, NHCOCF3, NHCOR, NHCONHR or NHCOOR
• R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;
• R1 is CH3, CH2F, CHF2, CF3, CH2CH3, or CF2CF3 and
• T is OH, OR, —NHCOCH3, or NHCOR.

A method of treating or reducing muscle wasting in a subject suffering from a muscle wasting disorder, comprising the step of administering to said subject a selective androgen receptor modulator (SARM) compound of formula (I):

• Wherein G is O or S
• X is O;
• Z is NO2, CN, COOH, COR, NHCOR or CONHR;
• Y is CF3, F, I, Br, Cl, CN, C(R)3 or Sn(R)3;
• Q is halogen, CN, NHCOCH3, NHCOCF3, NHCOR, NHCONHR or NHCOOR;
• R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;
• R1 is CH3, CH2F, CHF2, CF3, CH2CH3, or CF2CF3 and
• T is OH, OR, —NHCOCH3, or NHCOR.

A method of treating or reducing muscle protein catabolism in a subject suffering from a muscle wasting disorder, comprising the step of administering to said subject a selective androgen receptor modulator (SARM) compound of formula (I):

• wherein G is O or S
• X is O;
• Z is NO2, CN, COOH, COR, NHCOR or CONHR;
• Y is CF3, F, I, Br, Cl, CN, C(R)3 or Sn(R)3;
• Q is F, Cl, F, halogen, CN, NHCOCH3, NHCOCF3, NHCOR, NHCONHR or NHCOOR;
• R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;
• R1 is CH3, CH2F, CHF2, CF3, CH2CH3, or CF2CF3 and
• T is OH, OR, —NHCOCH3, or NHCOR.