Chemical compounds

A compound of Formula (I),

• wherein
• R1 is selected from:
• hydrogen, optionally-substituted C1-6alkyl, optionally substituted C1-6alkanoyl, optionally substituted aryl or optionally-substituted arylC1-6alkyl;
• R2 is an optionally-substituted mono or bi-cyclic aromatic ring;
• R3 is selected from a group of Formula (IIf):
• R4 is selected from:
• hydrogen, optionally substituted C1-6alkyl, optionally substituted aryl, C1-3perfluoroalkyl, cyano, nitro, halo, R9O(CH2)m—, R9C(O)N(R10)—, R9R10NC(O)N(R10)(CH2)m—, R9S(On)(CH2)m— or R9R10NC(O)—(CR9R10)t(CH2)m—;
• R5 is a group of Formula (III):
• R6 and R6a are independently selected from hydrogen, fluoro, optionally substituted C1-6alkyl, optionally-substituted aryl or optionally substituted arylC1-6alkyl, or R6 and R6a taken together and the carbon atom to which they are attached form a carbocyclic ring of 3-7 atoms, or R6 and R6a taken together and the carbon atom to which they are attached form a carbonyl group;
• or when A is not a direct bond the group
• forms a carbocyclic ring of 3-7 carbon atoms or a heterocyclic ring containing one or more heteroatoms;
• R9 and R10 are independently selected from:
• hydrogen, hydroxy, optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted arylC1-6alkyl, an optionally substituted carbocyclic ring of 3-7 atoms, optionally substituted heterocyclyl, optionally substituted heterocyclylC1-6alkyl or R9 and R10 taken together can form an optionally substituted ring of 3-9 atoms or R9 and R10 taken together with the carbon atom to which they are attached form a carbonyl group;
• R17 is independently selected from:
• hydrogen, hydroxy, cyano or optionally substituted C1-6alkyl;
• R18 is a group of formula R18a—C(R9R10)0-1— wherein R18a is selected from:
• R19OC(O)—, R9R10NC(O)—, R9R10N—, R9C(O)—, R9C(O)N(R10)—, R9R10NC(O)—, R9R10NC(O)N(R10)—, R9SO2N(R10)—, R9R10NSO2N(R10)—, R9C(O)O—, R9OC(O)—, R9R10NC(O)O—, R9O—, R9S(On)—, R9R10NS(On)—, hydrogen, optionally substituted C1-6alkyl, optionally substituted heterocyclyl;
• or R17 and R18 when taken together form an optionally substituted carbocyclic ring of 3-7 atoms or optionally substituted heterocyclyl;
• R19 is selected from:
• hydrogen, optionally substituted C1-6alky, optionally substituted aryl, optionally substituted arylC1-6alkyl, optionally substituted C3-7cycloalkyl, optionally substituted heterocyclyl or optionally substituted heterocyclyl C1-6alkyl;
• R21 and R22 are independently selected from hydrogen, optionally substituted C1-6alkyl, optionally substituted C3-7cycloalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylC1-6alkyl, optionally substituted C3-6alkenyl, optionally substituted C3-6alkynyl, —(C1-5alkyl)aa-S(On)—(C1-5alkyl)bb-;
• R9R10NC2-6alkyl, R9OC2-6alkyl or R9R10NC(O)C2-6alkyl, with the proviso that R9 and R10 independently or taken together are not optionally substituted aryl or optionally substituted arylC1-6alkyl;
• or
• R21 and R22 taken together form an optionally substituted non-aromatic heterocyclic ring;
• A is selected from:
• a direct bond;
• optionally-substituted C1-5alkylene wherein the optional substituents are independently selected from:
• optionally-substituted C1-6alkyl optionally-substituted aryl or optionally substituted arylC1-6alkyl;
• a carbocyclic ring of 3-7 atoms;
• a carbonyl group or —C(O)—C(RdRd)—, wherein Rd is independently selected from hydrogen and C1-2alkyl;
• G is selected from:
• hydrogen, halo, CN, NO2, N, O, S(On),C(O), C(R9R10)t, optionally substituted C2-6alkenylene, optionally substituted C2-6alkynylene, optionally substituted heterocyclyl or a direct bond to R18,
• m is an integer from 0 to 4;
• n is an integer from 0 to 2;
• t is an integer from 0 to 4;
• aa and bb are independently selected from 0 or 1 with the proviso that
• (i) when G is hydrogen, halo, CN or NO2 then R17 and R18 are both absent;
• and
• (ii) when G is O, S(On), C(O) or C(R9R10)t then G is substituted by a single group independently selected from the definition of R17 or R18 and when G is a direct bond to R18 then G is substituted by a single group selected from R18;
• or a salt or pro-drug thereof.