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US 7,547,717 B2Granted
Ion channel modulators
AssigneeWyeth
InventorsRobert Zelle, Vincent P. Galullo
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.
Claims7
A compound of formula (I) or pharmaceutical salt thereof
- wherein,
- R3 is Ar1 or Ar1—X—Y wherein,
- each Ar1 is cycloalkyl, aryl, heterocyclyl, or heteroaryl, each optionally substituted with one or more substituents;
- X is NR4, C(R4)2, or O;
- Y is C═O or lower alkyl;
- R1 is Ar2 or lower alkyl optionally substituted with Ar2;
- each Ar2 is independently cycloalkyl, aryl, heterocyclyl, or heteroaryl, each optionally substituted with one or more substituents;
- each R2 is independently selected from (CH2)mC(O)OR4, (CH2)mC(O)Ar3 and (CH2)mC(O)NR4R5;
- each R4 is independently selected from H and lower alkyl;
- each R5 is independently selected from H, lower alkyl and (CH2)pAr3;
- m is 1 or 2;
- n is 2 or 3;
- p is 0 or 1;
- each Ar3 is cycloalkyl, aryl, heterocyclyl, or heteroaryl, each optionally substituted with one or more substituents;
- each substituent for Ar1, Ar2 and Ar3 is independently selected from halogen, CN, NO2, OR6, SR6, S(O)2OR6, NR6R7, cycloalkyl, C1-C2perfluoroalkyl, C1-C2perfluoroalkoxy, 1,2-methylenedioxy, C(O)OR6, C(O)NR6R7, OC(O)NR6R7, NR6C(O)NR6R7, C(NR6)NR6R7, NR6C(NR7)NR6R7, S(O)2NR6R7, R8, C(O)R8, NR6C(O)R8, S(O)R8 and S(O)2R8;
- each R6 is independently selected from hydrogen and lower alkyl optionally substituted with one or more substituent independently selected from halogen, OH, C1-C4 alkoxy, NH2, C1-C4 alkylamino, C1-C4 dialkylamino and C3-C6 cycloalkyl;
- each R7 is independently selected from hydrogen, (CH2)qAr4 and lower alkyl optionally substituted with one or more substituent independently selected from halogen, OH, C1-C4 alkoxy, NH2, C1-C4 alkylamino, C1-C4 dialkylamino and C3-C6 cycloalkyl;
- each R8 is independently selected from (CH2)qAr4 and lower alkyl optionally substituted with one or more substituent independently selected from halogen, OH, C1-C4 alkoxy, NH2, C1-C4 alkylamino, C1-C4 dialkylamino and C3-C6 cycloalkyl
- each Ar4 is independently selected from C3-C6 cycloalkyl, aryl and heteroaryl, each optionally substituted with one to three substituents independently selected from halogen, OH, C1-C4 alkoxy, NH2, C1-C4 alkylamino, C1-C4 dialkylamino and C3-C6 cycloalkyl;
- and q is 0 or 1.
17 more elements
Dependencies are inferred from the claim text.