Methods for decreasing the toxic effects of nicotine on fetuses in pregnant women
AssigneesNabi Biopharmaceuticals, United States of America as Represented by the Secretary, DHHS Office of Technology Transfer, National Institutes of Health
InventorsSofiane Ennifar, Scott Winston, James Terrill, Steve Fuller
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Abstract
The present invention relates methods for reducing the adverse effects of nicotine. This application describes the use of nicotine carrier conjugates in decreasing the toxic effects of nicotine on a fetus.
Claims20
A method for reducing at least one adverse effect of nicotine on a fetus, comprising administering a nicotine-carrier conjugate to a human pregnant with a fetus, wherein the carrier is an immunogenic protein, and wherein the adverse effect is selected from low birth weight, premature delivery/birth, post-natal nicotine withdrawal and fetal death.
A method for increasing the gestation time of a fetus to the maximum normal gestational period in a pregnant human exposed to nicotine, comprising administering a nicotine-carrier conjugate to the pregnant human, wherein the carrier is an immunogenic protein.
A method for reducing the risk of spontaneous abortion of a fetus from a pregnant human exposed to nicotine, relative to the risk of abortion in a pregnant human not exposed to nicotine, comprising administering a nicotine-carrier conjugate to the pregnant human,
- wherein the carrier is an immunogenic protein.
A method for increasing the fertility of a female human exposed to nicotine, comprising administering a nicotine-carrier conjugate to the female human, wherein the female human is attempting to get pregnant,
- wherein the carrier is an immunogenic protein.
A method for inducing a protective response against nicotine in a human pregnant with a fetus, comprising administering a nicotine-carrier conjugate to the pregnant human at least one time during pregnancy,
- wherein the carrier is an immunogenic protein.
Dependencies are inferred from the claim text.