Spirocyclic cyclohexane compounds

A spirocyclic cyclohexane compound corresponding to formula I

• wherein
• R1 and R2 independently of one another represent H, C1-5-alkyl, branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted, or CHO;
• or
• R1 and R2 together represent CH2CH2OCH2CH2, CH2CH2NR11CH2CH2 or (CH2)3-6,
• wherein
• R11 denotes H;
• C1-5-alkyl, in each case saturated or unsaturated, branched or unbranched, mono- or polysubstituted or unsubstituted;
• C3-8-cycloalkyl, in each case saturated or unsaturated, mono- or polysubstituted or unsubstituted;
• aryl-, or heteroaryl, in each case mono- or polysubstituted or unsubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl which are bonded via C1-3-alkyl and are in each case mono- or polysubstituted or unsubstituted;
• R3 represents C1-5-alkyl, in each case saturated or unsaturated, branched or unbranched, mono- or polysubstituted or unsubstituted;
• C3-8-cycloalkyl, in each case saturated or unsaturated, mono- or polysubstituted or unsubstituted;
• aryl, in each case unsubstituted or mono- or polysubstituted;
• aryl or C3-8-cycloalkyl which are bonded via a C1-3-alkylene group and are in each case unsubstituted or mono- or polysubstituted;
• W represents NR4, O or S;
• wherein
• R4 denotes H;
• C1-5-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted;
• aryl, or heteroaryl, in each case substituted or unsubstituted;
• aryl, heteroaryl or cycloalkyl which are bonded via a C1-3-alkyl group and are in each case mono- or polysubstituted or unsubstituted;
• COR12;
• SO2R12,
• wherein
• R12 denotes H;
• C1-5-alkyl, in each case saturated or unsaturated, branched or unbranched, mono- or polysubstituted or unsubstituted;
• C3-8-cycloalkyl, in each case saturated or unsaturated, mono- or polysubstituted or unsubstituted;
• aryl-, or heteroaryl, in each case mono- or polysubstituted or unsubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl which are bonded via saturated or unsaturated C1-3-alkyl and are in each case mono- or polysubstituted or unsubstituted;
• OR13;
• NR14R15;
• R5 represents ═O;
• H;
• COOR13, CONR13, OR13;
• C1-5-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted;
• C3-8-cycloalkyl, saturated or unsaturated, unsubstituted or mono- or polysubstituted;
• aryl-, or heteroaryl, unsubstituted or mono- or polysubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl which are bonded via C1-3-alkyl and are unsubstituted or mono- or polysubstituted;
• R6 represents H;
• F, Cl, NO2, CF3, OR13, SR13, SO2R13, SO2OR13, CN, COOR13, NR14R15;
• C1-5-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted;
• C3-8-cycloalkyl, saturated or unsaturated, unsubstituted or mono- or polysubstituted;
• aryl-, or heteroaryl, unsubstituted or mono- or polysubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl which are bonded via C1-3-alkyl and are unsubstituted or mono- or polysubstituted;
• or
• R5 and R6 together denote (CH2)n, where n=2, 3, 4, 5 or 6, wherein individual hydrogen atoms can also be replaced by F, Cl, Br, I, NO2, CF3, OR13, CN or C1-5-alkyl;
• R7, R8, R9 and R10 independently of one another represent H, F, Cl, Br, I, NO2, CF3, OR13, SR13, SO2R13, SO2OR13, SO2NH2 CN, COOR13, NR14R15;
• C1-5-alkyl, C3-8-cycloalkyl, unsubstituted or mono- or polysubstituted;
• aryl-, or heteroaryl, unsubstituted or mono- or polysubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl which are bonded via C1-3-alkyl and are unsubstituted or mono- or polysubstituted;
• wherein
• R13 denotes H;
• C1-5-alkyl in each case saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted;
• C3-8-cycloalkyl, in each case saturated or unsaturated, unsubstituted or mono- or polysubstituted;
• aryl-, or heteroaryl, unsubstituted or mono- or polysubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl which are bonded via C1-3-alkyl and are unsubstituted or mono- or polysubstituted;
• R14 and R15 independently denote H;
• C1-5-alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted;
• or C3-8-cycloalkyl, in each case saturated or unsaturated, unsubstituted or mono- or polysubstituted;
• aryl-, or heteroaryl, unsubstituted or mono- or polysubstituted;
• or aryl, C3-8-cycloalkyl or heteroaryl which are bonded via C1-3-alkyl and are unsubstituted or mono- or polysubstituted;
• or
• R14 and R15 together form CH2CH2OCH2CH2, CH2CH2NR16CH2CH2 or (CH2)3-6,
• wherein
• R16 denotes H;
• C1-5-alkyl saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted;
• X represents NR17;
• wherein
• R17 represents H;
• C1-5-alkyl, saturated or unsaturated, branched or unbranched;
• COR12 or SO2R12,
• wherein, with reference to alkyl, mono- or polysubstituted means substitution of one or more hydrogen radicals by F, Cl, Br, I, —CN, NH2, NH-alkyl, NH-aryl, NH-heteroaryl, NH-cycloalkyl, NH-alkyl-aryl, NH-alkyl-heteroaryl, NH-alkyl-OH, N(alkyl)2, N(alkyl-aryl)2, N(alkyl-heteroaryl)2, N(cycloalkyl)2, N(alkyl-OH)2, NO2, SH, S-alkyl, S-aryl, S-heteroaryl, S-alkyl-aryl, S-alkyl-heteroaryl, S-cycloalkyl, S-alkyl-OH, S-alkyl-SH, OH, O-alkyl, O-aryl, O-heteroaryl, O-alkyl-aryl, O-alkyl-heteroaryl, O-cycloalkyl, O-alkyl-OH, CHO, C(═O)C1-6-alkyl, C(═S)C1-6-alkyl, C(═O)aryl, C(═S)aryl, C(═O) C1-6-alkyl-aryl, C(═S)C1-6-alkyl-aryl, C(═O)-heteroaryl, C (═S)-heteroaryl, C(═O)-cycloalkyl, C(═S)-cycloalkyl, CO2H, CO2-alkyl, CO2-alkyl-aryl, C(═O)NH2, C(═O)NH-alkyl, C(═O)NHaryl, C(═O)NH-cycloalkyl, C(═O)N(alkyl)2, C(═O)N(alkyl-aryl)2, C (═O)N(alkyl-heteroaryl)2, C(═O)N(cycloalkyl)2, SO-alkyl, SO2-alkyl, SO2NH2, SO3H, PO(O—C1-6-alkyl)2, Si(C1-6-alkyl)3, Si(C3-8-cycloalkyl)3, Si(CH2-C3-8-cycloalkyl)3, Si(phenyl)3, cycloalkyl, aryl or heteroaryl on one or different atoms and wherein, with reference to aryl, heteroaryl and cycloalkyl, mono- or polysubstituted means substitution of one or more hydrogen atoms of the ring system by F, Cl, Br, I, CN, NH2, NH-alkyl, NH-aryl, NH-heteroaryl, NH-alkyl-aryl, NH-alkyl-heteroaryl, NH-cycloalkyl, NH-alkyl-OH, N(alkyl)2, N(alkyl-aryl)2, N(alkyl-heteroaryl)2, N(cycloalkyl)2, N(alkyl-OH)2, NO2, SH, S-alkyl, S-cycloalkyl, S-aryl, S-heteroaryl, S-alkyl-aryl, S-alkyl-heteroaryl, S-cycloalkyl, S-alkyl-OH, S-alkyl-SH, OH, O-alkyl, O-cycloalkyl, O-aryl, O-heteroaryl, O-alkyl-aryl, O-alkyl-heteroaryl, O-cycloalkyl, O-alkyl-OH, CHO, C(═O) C1-6-alkyl, C(═S)C1-6-alkyl, C(═O)aryl, C(═S)aryl, C(═O)-C1-6-alkyl-aryl, C(═S)C1-6-alkyl-aryl, C(═O)-heteroaryl, C(═S)-heteroaryl, C(═O)-cycloalkyl, C(═S)-cycloalkyl, CO2H, CO2-alkyl, CO2-alkyl-aryl, C(═O)NH2, C(═O)NH-alkyl, C(═O)NHaryl, C(═O)NH-cycloalkyl, C(═O)N(alkyl)2, C(═O)N(alkyl=aryl)2, C(═O)N(alkyl-heteroaryl)2, C(═O)N(cycloalkyl)2, S(O)-alkyl, S(O)-aryl, SO2-alkyl, SO2-aryl, SO2NH2, SO3H, CF3, ═O, ═S;
• alkyl, cycloalkyl, aryl or heteroaryl;
• on one or different atoms or a physiologically acceptable salt thereof.