4-amino-quinazolines

Compounds of the formula I

• in which
• R and R1 are independently of each other H, alkyl of 1-6 carbon atoms, OR5, Hal, N(R5)2, NO2, CN, CHO, COalkyl of 1-6 carbon atoms, CON(R5)2, COOR5, allyl, CH═CH—COOR5, CH═CHCON(R5)2, SO2alkyl of 1-6 carbon atoms or phenyl, which is unsubstituted or mono-, di- or trisubstituted by alkyl of 1-6 carbon atoms,
• R2 is H, alkyl of 1-6 carbon atoms, cycloalkyl, —(CH2)o—OR5, or —(CH2)o—OR6,
• R3 is
• R4 is Ar,
• R5 is H or alkyl of 1-6 carbon atoms,
• R6 is benzo[1,3]dioxol-5-yl,
• R7 is H, alkyl of 1-6 carbon atoms, cycloalkyl or (CH2)q—OR5,
• Q is S,
• Y is a direct bond,
• Ar is phenyl, naphthyl or biphenyl, which is unsubstituxed or mono-, di- or trisubstituted by alkyl of 1-6 carbon atoms, OR5, cycloalkyloxy, O—(CH2)p-Ph, CF3,OCF3, Hal, CN, CHO, COalkyl of 1-6 carbon atoms, COOR5, —(CH2)p—N(R7)2, NR5—COalkyl of 1-6 carbon atoms, NO2, SO2N(R5)2, mor, SO2-mor, 5-methyl-3-oxo-2,4-dihydropyrazol-2-yl, naphthyl or Her2,
• Het2 is a unsaturated mono- or bicyclic heterocyclic radical having 5 to 10 ring members, where 1 or 2 N and/or 1 or 2 S or O atoms can be present and the heterocyclic radical can be mono- or disubstituted by alkyl of 1-6 carbon atoms, Hal, OR5, CF3, OCF3, N(R5)2, —(CH2)p—(CHalkyl of 1-6 carbon atoms)q-N(R5)—(CH2)q—COR5, CHO, COalkyl of 1-6 carbon atoms or COOR5,
• Hal is F, Cl, Br or I,
• mor is morpholin-4-yl,
• Ph is phenyl,
• o is 1, 2, 3, 4, 5, 6 or 7,
• p is 0, 1, 2, 3 or 4,
• q is 1, 2, 3 or 4,
• and their pharmaceutically acceptable salts.