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US 7,547,700 B2Granted
Aryl-[4-halo-4(heteroarylmethylamino)-methyl]-piperidin-1-1yl]-methanone derivatives, methods for production and use thereof as medicaments
AssigneePierre Fabre Medicament
InventorsBernard Vacher, Bernard Bonnaud, Jean-Louis Maurel, Francis Colpaert
Life of this patent
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Abstract
The invention relates to compounds of general formula (1) in which X and Y=a carbon with a bonded hydrogen atom (CH) or a nitrogen atom, A=a methyl, fluoromethyl, cyano, hydroxyl, methoxy group, or a chlorine or fluorine atom on condition that when A=methyl (CH3) and X and Y both=a carbon bonded to a hydrogen atom, then B=a chlorine atom, B=a chlorine or a fluorine atom, D=a hydrogen, chlorine, fluorine atom, or a cyano or trifluoromethyl group and E=a hydrogen, fluorine or chlorine atom.
Claims12
A compound of general formula (1):
- in which:
- X represents a carbon atom linked to a hydrogen atom (CH) and Y represents a nitrogen atom, or
- X represents a nitrogen atom and Y represents a carbon atom linked to a hydrogen atom (CH);
- A represents a methyl (CH3), fluoromethyl (CH2F), cyano (C≡N), hydroxyl (OH) or methoxy (OCH3) radical or a chlorine or fluorine atom;
- B represents a chlorine atom or a fluorine atom;
- D represents a hydrogen atom, a chlorine atom, a fluorine atom, a cyano group (C≡N) or a trifluoromethyl group (CF3);
- E represents a hydrogen, fluorine or chlorine atom;
- the addition salts thereof with pharmaceutically acceptable mineral acids or organic acids, and also the tautomeric forms thereof.
5 more elements
Dependencies are inferred from the claim text.