Back to results
US 7,547,699 B2Granted
Tetracyclic 6 azapyrazinoindolines as 5HT2C receptor agonists for obesity
AssigneesHoffmann-La Roche Inc., Vernalis Research Limited
InventorsPaul Hebeisen, Nathaniel Monck, Hans Richter, Stephan Roever
Life of this patent
Estimating the term…
Abstract
The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.
Claims17
A compound of formula
- wherein
- R1 and R2 form together with the carbon atoms Ca and Cb to which they are attached
- R3 is hydrogen, alkyl or cycloalkyl;
- R4 is hydrogen, alkyl, cycloalkyl, alkylcarbonyl or cycloalkylcarbonyl;
- R5 is alkyl or cycloalkyl;
- R6 and R7 are independently selected from hydrogen, alkyl, cycloalkyl, hydroxyalkyl and alkoxyalkyl;
- R8 and R9 are independently selected from hydrogen, alkyl, cycloalkyl, hydroxyalkyl and alkoxyalkyl;
- R10 and R11 are independently selected from hydrogen and alkyl;
- and
- R12 and R13 are independently selected from hydrogen and alkyl;
- or pharmaceutically acceptable salts and esters thereof.
8 more elements
Dependencies are inferred from the claim text.