Back to results
US 7,547,697 B2Granted
Alkyl-pyridazine derivatives as 11b-HSD1 inhibitors
AssigneeHoffmann-La Roche Inc.
InventorsKurt Amrein, Daniel Hunziker, Bernd Kuhn, Werner Neidhart, Alexander V. Mayweg
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I): as well as pharmaceutically acceptable salts and esters thereof for use as pharmaceutical compositions.
Claims19
A compound of formula (I):
- wherein
- R1 is cycloalkyl, arylalkyl or aryloxyalkyl;
- R1 is cycloalkyl, arylalkyl or aryloxyalkyl;
- or
- R1 and R2 together with the carbon atoms Ca and Cb to which they are attached form
- R3 is hydrogen, alkyl, cycloalkyl or trifluoromethyl;
- R4 is 2,2-dimethyl-propyl, 3-methyl-butyl, iso-propyl, tert-butyl, cyclopropylmethyl, cyclopentylmethyl, 3,3-dimethyl-butyl or 1-cyclopropyl-1-methyl-ethyl;
- R5 is hydrogen, alkyl cycloalkyl or alkoxy;
- R6 is hydrogen, alkyl, cycloalkyl or alkoxy;
- R7 is hydrogen, alkyl, cycloalkyl or alkoxy;
- and pharmaceutically acceptable salts thereof.
8 more elements
Dependencies are inferred from the claim text.