Aminoquinoline derivatives and their use as adenosine A3 ligands

A compound of formula (I),

• wherein
• R1 is hydrogen atom or a straight or branched C1-4 alkyl;
• R2 is hydrogen atom or a straight or branched C1-4 alkyl;
• R3 is hydrogen atom,
• straight or branched C1-4 alkyl, or C3-6 cycloalkyl,
• phenyl, thienyl, or furyl, each of which is optionally substituted with one or more straight or branched C1-4 alkyl, straight or branched C1-4 alkoxy, or halogen atom, or
• six- or five-membered heteroaromatic ring containing one, two or three nitrogen atoms, or five-membered heteroaromatic ring containing one nitrogen atom and one oxygen atom, or one nitrogen atom and one sulphur atom, wherein the heteroaromatic ring is optionally substituted with one or more straight or branched C1-4 alkyl, straight or branched C1-4 alkoxy, or halogen atom;
• R4 and R5 taken together with the nitrogen atom to which they are attached form a group of formula a.)
• R6 is hydrogen atom, straight or branched C1-4 alkyl,
• phenyl, benzyl, thienyl, or furyl, each of which is optionally substituted with methylenedioxy, or one or more straight or branched C1-4 alkyl, straight or branched C1-4 alkoxy, hydroxy, trifluoromethyl, cyano or halogen atom, or
• six- or five-membered heteroaromatic ring containing one, two or three nitrogen atoms, or one nitrogen atom and one oxygen atom, or one nitrogen atom and one sulphur atom, wherein the heteroaromatic ring is optionally substituted with one or more straight or branched C1-4 alkyl, straight or branched C1-4 alkoxy or halogen atom;
• R7 and R8 independently are hydrogen atom,
• straight or branched C1-4 alkyl or C3-6 cycloalkyl;
• X is —CH2—, —NH—, —NR9—, sulphur atom, oxygen atom, sulpho or sulphoxy;
• R9 is straight or branched C1-4 alkyl or C3-6 cycloalkyl;
• Z is—O—;
• n is zero, 1 or 2;
• m is 1, 2, or 3;
• o is 1, 2, or 3;
• p is zero or 1;
• and
• r is zero or 1, or
• a salt, or tautomer, desmotrop or optically active isomer thereof, or a salt of the tautomer, desmotrop or optically active isomer.