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US 7,547,690 B2Granted
Compounds for the treatment of Hepatitis C
AssigneeBristol-Myers Squibb Company
InventorsRobert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
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Abstract
The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
Claims13
A compound of formula I
- where:
- R1 is CO2R5 or CONR6R7;
- R2 is
- R3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, or alkoxy;
- R4 is cycloalkyl;
- R5 is hydrogen or alkyl;
- R6 is hydrogen, alkyl, alkylSO2, alkenylSO2, cycloalkylSO2, (cycloalkyl)alkylSO2, haloalkylSO2, (R9)(R10)NSO2, or (R11)SO2;
- R7 is hydrogen or alkyl;
- R8 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl, cycloalkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylSO2, cycloalkylSO2, haloalkylSO2, aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, benzyl, benzyloxycarbonyl, or pyridinyl;
- R9 is hydrogen or alkyl;
- R10 is hydrogen or alkyl;
- R11 is azetidinyl, pyrrolidinyl, piperidinyl, N-(R12)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homomorpholinyl, tetrahydrofuranyl, tetrahydropyranyl, (tetrahydrofuranyl)alkyl, or (tetrahydropyranyl)alkyl;
- and
- R12 is hydrogen or alkyl;
- or a pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.