US 7,547,687 B2 · Therapeutic treatment methods

Abstract

The invention relates to the use of compounds to ameliorate or treat a condition such as a cystic fibrosis, neutropenia or other exemplified conditions. Exemplary compounds that can be used include 3β-hydroxy-17β-aminoandrost-5-ene, 3β-hydroxy-16α-fluoro-17β-aminoandrost-5-ene, 3α-hydroxy-16α-fluoro-17β-aminoandrost-5-ene, 3β-hydroxy-16β-fluoro-17β-aminoandrost-5-ene, 1α,3β-dihydroxy-4α-fluoroandrost-5-ene-17-one, 1α,3β,17β-trihydroxy-4α-fluoroandrost-5-ene, 1β,3β-dihydroxy-6α-bromoandrost-5-ene, 1α-fluoro-3β,12α-dihydroxyandrost-5-ene-17-one, 1α-fluoro-3β,4α-dihydroxyandrost-5-ene and 4α-fluoro-3β,6α,17β-trihydroxyandrostane.

Claims19

Dependent claims

A composition comprising one or more excipients and a compound having the structure

wherein the dotted lines are optional double bonds;
R1 is —OH or an ester;
R2 is —H, —OH or an ester;
R3 is —H, —OH, a halogen or an ester;
R4 in the β-configuration is —OH, an ester or an amino acid and R4 in the α-configuration is —H or optionally substituted alkynyl;
R5 is —CH3 or —C2H5;
R10A is —OH or R10A is —H or —OH when R2 is —OH or an ester;
and
R10B is a halogen.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

11/674,128Filed 12 Feb 2007 · continuation

Priority

28 Aug 2002

Published

US 2007/0275938 A129 Nov 2007

Granted

16 Jun 2009

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 31/56
Medicinal preparations containing organic active ingredients: compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives…
A61K 31/57
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids: substituted in position 17 beta by a chain…
A61K 31/58
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids: containing heterocyclic rings, e.g. danazol,…
A61P 19/02
Drugs for skeletal disorders: for joint disorders, e.g. arthritis, arthrosis

Family

Application60/407,146Us provisional application · filed 28 Aug 2002

Application60/408,332Us provisional application · filed 4 Sep 2002

Application60/479,257Us provisional application · filed 17 Jun 2003

Application10/651,515Parent of this continuation-in-part · filed 28 Aug 2003

Application10/728,400Parent of this continuation · filed 5 Dec 2003

US 2007/0275938 A1Pre-grant publication · published 29 Nov 2007

Application10/728,400Parent of this continuation-in-part

US 2004/0138187 A1Published application

US 2005/0101581 A1Published application

US 7,547,687 B2This patent

From the US filing history. Foreign family members aren’t listed.

Therapeutic treatment methods

Life of this patent

Therapeutic treatment methods

Life of this patent

Abstract

Claims19