Therapeutic substituted pyrrolidone compounds
AssigneeAllergan, Inc.
InventorDavid W. Old
Life of this patent
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Abstract
Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof are disclosed herein. Details are provided herein. Compositions, methods, and medicaments related thereto are also disclosed.
Claims19
A compound having the structure:
- or a pharmaceutically acceptable salt thereof;
- wherein a dashed line represents the presence or absence of a bond;
- Y is an organic acid functional group, or an amide or ester thereof comprising from 0 to 12 carbon atoms;
- or Y is hydroxymethyl or an ether thereof comprising from 0 to 12 carbon atoms;
- or Y is a tetrazolyl functional group;
- Ar is interarylene or interheteroarylene;
- and
- B is X-aryl or X-heteroaryl, wherein X is a covalent bond, CH2, CH2CH2, CH2O, or CH2S.
A method comprising administering an effective amount of a therapeutic agent to a mammal for one or more therapeutic purposes chosen from the treatment of glaucoma or ocular hypertension, the treatment of an irritable bowel disease, the maintenance of colonic mucous, or a combination thereof;
- said therapeutic agent comprising a compound of the formula
- a pharmaceutically acceptable salt of said compound or a combination thereof;
- wherein a dashed line represents the presence or absence of a bond;
- Y is an organic acid functional group, or an amide or ester thereof having from 0 to 12 carbon atoms;
- or Y is hydroxymethyl or an ether thereof having from 0 to 12 carbon atoms;
- or Y is a tetrazolyl functional group;
- Ar is interarylene or interheteroarylene;
- and
- B is aryl or heteroaryl.
A composition comprising a compound, said composition being an aqueous liquid which is formulated for topical ophthalmic administration, said compound represented by the formula
- or a pharmaceutically acceptable salt thereof;
- wherein a dashed line represents the presence or absence of a bond;
- Y is an organic acid functional group, or an amide or ester thereof having from 0 to 12 carbon atoms;
- or Y is hydroxymethyl or an ether thereof having from 0 to 12 carbon atoms;
- or Y is a tetrazolyl functional group;
- Ar is interarylene or interheteroarylene;
- and
- B is aryl or heteroaryl.
Dependencies are inferred from the claim text.