Back to results
US 7,547,681 B2Granted
Surface receptor antigen vaccines
AssigneeUniversity of Washington
InventorsNathalie B Scholler, Mary L Disis, Ingegerd Hellstrom, Karl Erik Hellstrom
Life of this patent
Estimating the term…
Abstract
The invention provides compositions and methods directed to cell surface receptor antigen specific vaccines. More specifically, vaccines are provided that induce or enhance host antibody titers specific for cell surface receptor antigens and that include recombinant expression constructs containing nucleic acids encoding a target cell surface receptor antigen and one or more immune response altering molecules, or the expressed products themselves.
Claims11
A composition for eliciting antibodies specific for a cell surface receptor antigen, comprising:
- a) a first recombinant expression construct containing at least one promoter operably linked to a nucleic acid sequence encoding a cell surface receptor antigen, wherein the cell surface receptor antigen is selected from the group consisting of HER1, HER2, HER3 and HER4;
- b) a second recombinant expression construct containing at least one promoter operably linked to a nucleic acid sequence encoding a first immune response altering molecule wherein said first immune response altering molecule comprises 4-1BB-ligand;
- and
- c) a nucleic acid sequence encoding a second immune response altering molecule selected from the group consisting of CD80/B7.1 and CD86/B7.2.
1 more element
Dependencies are inferred from the claim text.