Methods and compositions for the repair and/or regeneration of damaged myocardium
AssigneeNew York Medical College
InventorsPiero Anversa, Donald Orlic
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Abstract
Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed.
Claims22
A method for restoring functional and structural integrity to damaged myocardium in a subject in need thereof, the method comprising administering to the subject an effective amount of a cytokine to form a chemotactic gradient in the subject's heart sufficient to cause adult cardiac stem cells resident in the heart to migrate to the area of the damaged myocardium, wherein said gradient is formed by multiple injections of said cytokine from storage areas of said resident adult cardiac stem cells to a border zone of the damaged myocardium, and wherein the functional and structural integrity of the damaged myocardium is restored following the migration of adult cardiac stem cells to the area of damaged myocardium.
A method for restoring functional and structural integrity to damaged myocardium in a subject in need thereof, the method comprising administering to the subject an effective amount of at least one isolated cytokine to form a chemotactic gradient in the subject's heart sufficient to cause adult cardiac stem cells resident in the heart to replicate and migrate to the area of the damaged myocardium, wherein said gradient is formed by multiple injections of said at least one cytokine from storage areas of said resident adult cardiac stem cells to a border zone of the damaged myocardium, and wherein the functional and structural integrity of the damaged myocardium is restored following the migration of adult cardiac stem cells to the area of damaged myocardium.
Dependencies are inferred from the claim text.