Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production
AssigneeThe Johns Hopkins University
InventorsYoung He Ko, Jean-Francois H. Geschwind, Peter L. Pedersen
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Abstract
The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising such inhibitors and methods for administering them intraarterially directly to a tumor, as well as methods for identifying compositions that selectively inhibitor ATP production for use in the invention.
Claims13
A method of treating primary or secondary liver cancer in a subject comprising administering to a subject having a primary or secondary liver tumor an effective amount of a 3-halopyruvate or a salt thereof delivered by transcatheter hepatic intraarterial injection into the liver.
A method of treating primary or secondary liver cancer in a subject comprising administering to a subject having a primary or secondary liver tumor a therapeutically effective amount of a 3-halopyruvate or a salt thereof and fluorouracil delivered by transcatheter hepatic intraarterial injection into the liver.
A method of treating primary or secondary liver cancer in a subject comprising administering to a subject having a primary or secondary liver tumor delivered by transcatheter hepatic intraarterial injection into the liver an effective amount of a compound represented by formula:
- wherein, independently of each occurrence:
- X represents a halide;
- R1 represents OR, H, N(R″)2, C1-C6 alkyl, C6-C12 aryl, C1-C6 heteroalkyl, or C6-C12 heteroaryl;
- R″ represents H, C1-C6 alkyl, or C6-C12 aryl;
- R represents H, alkali metal, C1-C6 alkyl, C6-C12 aryl or C(O)R′;
- and
- R′ represents H, C1-C20 alkyl or C6-C12 aryl, or a salt thereof.
A method of treating primary or secondary liver cancer in a subject comprising administering to a subject having a primary or secondary liver tumor delivered by transcatheter hepatic intraarterial injection into the liver an effective amount of a compound represented by formula:
- wherein, independently of each occurrence:
- X represents a halide;
- R1 represents OR, H, N(R″)2, C1-C6 alkyl, C6-C12 aryl, C1-C6 heteroalkyl, or C6-C12 heteroaryl;
- R″ represents H, C1-C6 alkyl, or C6-C12 aryl;
- R represents H, alkali metal, C1-C6 alkyl, C6-C12 aryl or C(O)R′;
- and
- R′ represents H, C1-C20 alkyl or C6-C12 aryl, or a salt thereof and administering fluorouracil to said subject.
A method of treating a liver tumor that has metastasized within the liver of a subject an effective amount of a 3-halopyruvate or a salt thereof delivered by transcatheter hepatic intraarterial injection into the liver.
Dependencies are inferred from the claim text.